Downregulation of signalling molecules involved in angiogenesis of prostate cancer cell line (PC-3) by kombucha (lyophilized)

Authors:
Thummala Srihari, Ramachandran Arunkumar, Jagadeesan Arunakaran, Uppala Satyanarayana

Abstract:
Kombucha is a fermented tea beverage produced by fermenting sugared black tea with tea fungus (kombucha). Prostate cancer, like other solid tumors, is also angiogenesis-dependent. The development of prostate cancer is a multi-step process, advancing from high-grade prostatic intraepithelial neoplasia (PIN) to focal carcinoma, then to invasive carcinoma, and finally to metastatic disease. In this study, we examined the anti-angiogenic effect of kombucha on angiogenesis stimulators/regulators (gene expression of human inducible factor-1, vascular endothelial growth factor, interleukin-8, cyclooxygenase-2, and matrix metalloproteinases) in human androgen-independent prostate cancer cell line. Kombucha remarkably inhibits the angiogenesis through the alterations in the expression of angiogenic stimulators. Our study demonstrates that kombucha significantly decreases the survival of prostate cancer cells by downregulating the expression of angiogenesis stimulators. These findings suggest that kombucha may be useful for prostate cancer treatment or prevention.

Keywords: black tea, cancer, cells, ph, protein



Country: India

Citation: ABSTRACT - Biomedicine & Preventive NutritionVolume 3, Issue 1, January-March , Pages 53-58

Study Mailing Address:
Department of Biochemistry, Siddhartha Medical College, Dr NTR University of Health Sciences, Vijayawada 520008, AP, India
b Department of Endocrinology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India
c Dr. Pinnamaneni Siddhartha Institute of Medical Sciences, Chinaoutapally 521286, Gannavaram-Mdl, Krishna-Dt., AP, India

Date Updated: March 29, 2020