Effects of Kombucha on oxidative stress induced nephrotoxicity inrats

Authors:
Ola Ali Gharib

Abstract:
Background: Trichloroethylene (TCE) may induce oxidative stress which generates free radicals
and alters antioxidants or oxygen-free radical scavenging enzymes. Methods: Twenty male albino rats were divided into four groups: (1) the control group treated with vehicle, (2) Kombucha (KT)-treated group, (3) TCE-treated group, and (4) KT/TCE-treated group. Kidney lipid peroxidation, glutathione content, nitric oxide (NO), and total blood-free radical concentrations were evaluated. Serum urea, creatinine level, gamma-glutamyl transferase (GGT), and lactate dehydrogenase (LDH) activities were also measured. Results: TCE administration increased the malondiahyde (MDA) and NO contents in kidney, urea and creatinine concentrations in serum, total free radical level in blood and GGT and LDH activities in serum, whereas it decreased the glutathione (GSH) level in kidney homogenate. KT administration significantly improved lipid peroxidation and oxidative stress induced by TCE. Conclusion: The present study indicates that Kombucha may repair damage caused by environmental pollutants such as TCE and may be beneficial to patients suffering from renal impairment.


Keywords: antioxidant, radical scavenging, kidney, biomedical, in vivo



Country: Egypt

Citation: Chinese Medicine 2009, 4:23 doi:10.1186/1749-8546-4-23

Study Mailing Address:
Drug Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City,
Cairo, Egypt

Date Updated: January 13, 2021