Effects of synchronized oral administration and topical application of Kombucha on third-degree burn wounds regeneration in mature rats

Authors:
Kazem Parivar, Parichehr Yaghmaie, Nasim Hayati Rudbari, Parastoo Mohammadi Mohaghegh

Abstract:
Background: According to evidence of the therapeutic effects of Komboucha, this study was conducted to investigate the facts of Kombucha's topical application Synchronized with Kombucha tea oral administration on third-degree burn wounds healing in Wistar rats. Materials and Methods: In this experimental study, forty Wistar male rats weighing 150-200g were subjected to deep-burn injuries under general anesthesia in the sterile condition. They were randomly divided into four groups, including control (the group without any treatment), sham (sweetened tea treated group), experimental1 (KT treated group), and experimental2 (the group that managed with KT oral administration and homogeneous Kombucha symbiont topical application). After 21-day treatment, the rats were sacrificed using an overdose of anesthetic. Macroscopic and microscopic characteristics of the wound were studied. Results: Macroscopic evaluation revealed closure of burn wounds in experimental groups ultimately. Histological studies showed that skin, keratinocyte layer, epidermis and hypodermis thicknesses in the experimental one and experimental two groups and also the number and diameter of hair follicles in the experimental 1 group were significantly increased compared with the control group (P<0.001). Conclusion: Synchronized oral administration and topical application of Kombucha probably lead to healing acceleration and scar reduction of full-thickness burn wounds.

Keywords: rats, scar reduction, topical



Country: Iran

Citation: Medical Science Journal of Islamic Azad Univeristy Tehran Medical Branch Volume 22, Number 1

Study Mailing Address:
MSc student Islamic Azad University, Science and Research Campus, Tehran, Iran

Date Updated: January 14, 2021