In vivo stud of the effect of kombucha on the Injured skin of adult NMRI mice strain



Authors:
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Abstract:
Background: Kombucha is used for the treatment of several diseases, including wound healing, in traditional medicine. Due to its effective abilities, such as antibiotic activities, detoxification, and its impact on skin luminosity, we attempted to determine its effect on Injured skin in vivo conditions. Materials and methods: 30 male NMRI strain were randomly assigned in control (Injured skin), sham (exposed with sweet tea), and experimental (received Kombucha) groups. A 3mm diameter wound with complete skin thickness was made on the back of each mouse. Treatment with Kombucha was applied three times a day for 18 days. At the end of the study, a histological study was carried out on the under-treatment tissues. Results: A significant decrease in wound diameter was observed in the experimental group compared to the control group (P<0.001). Furthermore, significant increased epidermal thickness and decreased derm and hypoderm thickness were seen in the experimental group compared to the control group (P<0.05). Hair follicle diameter was significantly increased in the experimental group compared to the control group, while skin thickness diameter was in coordination with the control group. Conclusion: External use of Kombucha on open wound skin with complete skin thickness effectively accelerates the wound-healing procedure and also increases hair follicle diameter and length in vivo condition.

Keywords: kombucha, injured skin, wound healing



Country: Iran

Citation: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY WINTER , Volume 21 , Number 4 (66); Page(s) 262 To 267.

Study Mailing Address:
Professor, Department of Animal Biology, Islamic Azad University, Science and Research Campus, Tehran, Iran

Date Updated: March 9, 2020

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