Possible Protective Effect of Kombucha Tea Ferment on Cadmium Chloride Induced Liver and Kidney Damage in Irradiated Rats
Nashwa Kamel Ibrahim
Kombucha Tea Ferment (KT), was given to male albino rats, (1ml/Kg of body weight), via gavages, during 2 weeks before intraperitoneal administration of 3.5 mg/Kg body weight CdCl2 and/or whole-body -irradiation with 4Gy, and during 4 weeks after each treatment. Hepatic and nephritic pathological changes included significant increases in serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) activities, and creatinine and urea contents with a significant decrease in serum total antioxidant capacity (TAC). Increase in oxidative stress markers in liver and kidney tissues expressed by a significant increase in malondialdehyde (MDA) and nitric oxide (NO) contents associated with significant depletion in superoxide dismutase (SOD) and catalase (CAT) activities, and reduced glutathione (GSH) content was recorded. KT administration results in the recovery of all the pathological changes. It could be concluded that KT might protect the liver and kidney from oxidative damage induced by exposure to cadmium and/ or -irradiation.
Keywords: cadmium, kombucha, radiation, rats
Citation: International Journal of Biological and Life Sciences, 9(1), 8-11.
Study Mailing Address:
Nashwa Kamel Ibrahim, Department of Radiation Biology,
National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt
Date Updated: March 13, 2020