Protective effect of Kombucha tea on brain damage induced by transient cerebral ischemia and reperfusion in rat

Authors:
Najmeh Kabir, Mahbubeh Setorki

Abstract:
The aim of the study was to investigate the potential neuroprotective effects of Kombucha on cerebral damage induced by ischemia in rats (n=99). Cerebral infarct volume in the ischemic rats received Kombucha solution showed no significance alteration. However, the permeability of the blood-brain barrier significantly decreased in both ischemic rats received 15 mg/kg Kombucha tea and Sham group. In addition, brain water content in the ischemic groups treated with Kombucha solution was significantly higher than the Sham group, although the right hemispheres in all of the treated groups illustrated higher brain water content than the left ones. Brain anti-oxidant capacity elevated in the ischemic rats treated with Kombucha and in the Sham group. Brain and plasma malondialdehyde concentrations significantly decreased in both of the ischemic groups injected with Kombucha. The findings suggest that Kombucha tea could be useful for the prevention of cerebral damage.

Keywords: brain damage, kombucha tea, rat, reperfusion, transient cerebral ischemia



Country: Iran

Citation: Bangladesh Journal of Pharmacology . 2016, Vol. 11 Issue 3, p675-683. 9p. 1

Study Mailing Address:
Department of Biology, Izeh Branch, Islamic Azad University, Izeh

Date Updated: January 25, 2021