Protective effect of Kombucha Tea on Liver Damage Induced by Thioacetamide in Rats

Authors:
Najmeh Kabiri, Mahboobeh Ahangar Darabi, Mahmoud Rafieian-Kopaei, Mahbubeh Setorki, Monir Doudi

Abstract:
The aim of this study is to evaluate the possible protective effects of Kombucha tea against thioacetamide-induced liver damage in rats. A total of 24 male Wistar rats were divided into four groups: Control, treated with thioacetamide (TAA) treated with TAA, and then Kombucha tea, treated with Kombucha tea and then TAA; following 3 weeks of treatment. All the animals were killed, and liver tissue samples were obtained for histopathological investigation. The data showed that TAA significantly increased aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) but not bilirubin. The treatment by Kombucha tea promoted a significant reduction in serum enzyme levels AST, ALT, ALP, LDH, and reduction in bilirubin content. The results show that the Kombucha tea has protective effects against the thioacetamide-induced hepatotoxicity that might be due to the antioxidant activities of these plants.

Keywords: hepatoprotective, thioacetamide, kombucha tea, rat



Country: Iran

Citation: Journal of Biological Sciences, 14(5), 343.

Study Mailing Address:
Mahboobeh Ahangar Darabi, Dept of Biology, Faculty of Sciences, Isfahan University, Isfahan, Iran

Date Updated: March 13, 2020